William's father Robert, was granted the Earldom of Suffolk in its second creation in March 1337. The family take their name from their manor in Ufford in Suffolk, it being descended through the family of Peyton. The Ufford name died along with William in 1382, their bloodline however continued through three daughters.
William Ufford was buried at Campsey Priory, in Campsea Ashe, Suffolk.